Suzanne Scarlata
Unraveling Hidden Cell Signaling Pathways Using Biophysical Methods: Application to the Gαq/{Phospholipase Cβ Signaling SystemJournal of Physical Chemistry 2024, 128, 9, 2057–2064. DOI: 10.1021/acs.jpcb.4c00343


Suzanne ScarlataImanol González-BurgueraGuanyu LinMaider López de JesúsMiquel Saumell-EsnaolaSergio BarrondoGontzal García del Caño,  Joan Sallés

[Preprint] PLCβ1 By-Passes Early Growth Response-1 to Induce and Maintain the Differentiation of Neuronal Cells

DOI 10.21203/

Repeated Activation of Gαq by neurotransmitters causes age-dependent accumulation of stress granules in C.elegans

Advance Biology (Under Review) DOI: 10.1101/2023.12.04.569992 (BioRxIV)


Guanyu Lin, Madison Rennie, Ayobami Adeeko, and Suzanne Scarlata 

The role of calcium in neuronal membrane tension and synaptic plasticity

Biochemical Society Transactions, March 27, 2024, doi: 10.1042/BST20231518



S. Yerramilli, J. Reisinger, S. Yerramilli, R. Hammerlin, S. Lindberg, K. Plante. A. Ross, S. Scarlata and A. Gericke

[Preprint] IQGAP1 enhances EGFR signaling by Promoting Oligomerization and Preventing Degradation

DOI 10.21203/



Lela Jackson,  V. Siddartha Yerramilli, and Suzanne Scarlata

Live Cell Fluorescence Imaging Shows Neurotransmitter Activation Promotes Aggregation of the Intracellular Domain of Amyloid Precursor Protein

J Membrane Biol (2022).  doi: 10.1007/s00232-022-00266-6


Rameez AliSangram S. ParelkarPaul R. ThompsonSusan Mitroka-BatsfordSiddartha YerramilliSuzanne F. Scarlata, Katelyn S. MistrettaJeannine M. CoburnAnita E. Mattson

Phomoxanthone A Targets ATP Synthase 

Chemistry a European Journal (2022), doi: 10.1002/chem.20220239


Wang, S.; Scarlata, S.; Rahbar, N.

Curling and Self-Healing of Enzymatic Construction Materials Using Nanoparticles

Cell Reports Physical Science, Volume 0, Issue 0, 101039 doi: 10.1016/j.xcrp.2022.101039


Madison Rennie, Guanyu Lin, and Suzanne Scarlata

Multiple Function of Phospholipase C at a Glance (Article Type: Cell Science at a Glance)

J Cell Science (2022) 135 (18): jcs260282


Jackson, L.; Rennie, M.; Poussaint A.; Scarlata, S. F. 

Activation of Gαq sequesters specific transcripts into Ago2 particles.

Sci Reports 12, 8758 (2022).


Qifti, A.;  Balaji, S.; Scarlata, S. F. 

Deformation of caveolae impacts global transcription and translation processes through relocalization of cavin-1

Biophysical Journal 2022, 121 (3, Supplement 1), 258a. doi: 10.1016/j.bpj.2021.11.1474

S. Wang, S. F. Scarlata and N. Rahbar

A self-healing enzymatic construction material 

Matter 2022 Vol. 5 Issue 3 Pages 957-974

V. S. Yerramilli, A. H. Ross, S. Scarlata and A. Gericke

IQGAP1 scaffolding links phosphoinositide kinases to cytoskeletal reorganization

Biophysical Journal 2022 Vol. 121 Issue 5 Pages 793-807

S. Scarlata and V. S. Yerramilli

Design of a Rapid and Reversible Fluorescence Assay to Detect Covid-19 and other Pathogens

Medical Research Archives 2022 Vol. 10 Issue 4


Qifti A, Jackson L, Singla A, Garwain O, Scarlata S. with Qifti Jackson et al and Supplementary Information

Stimulation of phospholipase Cβ1 by Gαq promotes the assembly of stress granule proteins.

Sci Signal. 2021 Oct 19;14(705):eaav1012. doi: 10.1126/scisignal.aav1012. Epub 2021 Oct 19. PMID: 34665639.


Shuai Wang, Suzanne F Scarlata, Nima Rahbar, Jessica R. Rosewitz 

An enzymatic self-healing cementitious material 

Applied Materials Today 2021 Vol. 23 Pages 101035


Nima Rahbar, Jessica Anne Rosewitz, Suzanne Frances Scarlata

Method for enzymatic repair of cementitious surfaces, U.S. patent number 10,647,617  (Worcester Polytechnic Institute).  2020-05-12

Design Of A Rapid And Reversible Fluorescence Assay To Detect Covid-19 And Other Pathogens

R. C. Calizo, M. K. Bell, A. Ron, M. Hu, S. Bhattacharya, N. J. Wong, W.G. M. Janssen, G. Perumal, P. Pederson, S. Scarlata, J. Hone, E. U.Azeloglu, P. Rangamani & R. Iyengar

Cell shape regulates subcellular organelle location to control early Ca2+ signal dynamics in vascular smooth muscle cells
Sci Rep 10. 20 October 2020

Sayed Iman Mousavi, Katherine M. Pearce, Suzanne Scarlata, Erkan Tüzel

Re-track: Software to analyze the retraction and protrusion velocities of neurites, filopodia and other structures
Analytical Biochemistry Feb 17


Garwain, O.; Pearce, K. M.; Jackson, L.; Carley, S.; Rosati, B.; Scarlata, S. S.

Simulation of the Gαq /Phospholipase Cβ1 Signaling Pathway Returns Differentiated PC12 Cells to a Stem-like State.
FASEB J 2020,  34  12663-12673


Garwain, O.; Yerramilli, V. S.; Romero, K.; Scarlata, S.,

The Gαq/phospholipase Cβ signaling system represses tau aggregation.
Cell Signal 2020, 71, 109620.


Lela Jackson, Androniqi Qifti, Katherine M Pearce, Suzanne Scarlata.

Regulation of bifunctional proteins in cells:  Lessons from the phospholipase Cβ / G protein pathway
Protein Science. 2019 Dec 22


Katherine M. Pearce, Miriam Bell, Will H. Linthicum, Qi Wen, Jagan Srinivasan, Padmini Rangamani, and Suzanne Scarlata

Gαq-mediated calcium dynamics and membrane tension modulate neurite plasticity
MBoC. 2019 Dec 11 doi:10.1091/mbc.E19-09-0536

Scarlata, S.,

The role of phospholipase Cβ on the plasma membrane and in the cytosol: How modular domains enable novel functions.
Advances in Biological Regulation Jul 4 2019, 73, 100636.


Androniqi Qifti, Osama Garwain, Suzanne Scarlata

Mechanical Stretch Redefines Membrane Gαq–Calcium Signaling Complexes
JMB. 2019 Feb 11 doi:10.1007/s00232-019-00063-8


Mary D Frame*, Anthony M Dewar, Rhodora C Calizo, Androniqi Qifti, and Suzanne F Scarlata

Nitrosative stress uncovers potent β-2-adrenergic receptor linked vasodilation further enhanced by blocking clathrin endosome formation.
Am J Physiol Heart Circ Physiol 2018 Mar 23 doi:10.1152/ajpheart.00365.2017


Osama Garwain, Kaitlyn Valla, and Suzanne Scarlata

Phospholipase Cβ1 regulates proliferation of neuronal cells
FASAB J. 2018 Jan 12



Richard Thompson and Suzanne Scarlata

  • Fluorescence Made Easier: Fluorescence Techniques for the Novice. Episode 1: The Basics  
  • Fluorescence made easier: fluorescence techniques for the novice. Episode 2: Using fluorescence anisotropy or polarization to view intermolecular associations
  • Fluorescence Made Easier: Fluorescence Techniques for the Novice Episode 3:. Avoiding Those Pesky Artifacts: Sources of Error in Spectra and Steady State Measurements, 

Reviews in Fluoresce 2017


Scarlata, S.; Singla, A.; Garwain, O.,

Phospholipase Cβ interacts with cytosolic partners to regulate cell proliferation.
Advances in Biological Regulation 2017.


Shriya Sahu, Leo Williams, Alberto Perez, Finly Philip, Giuseppe Caso, Walter Zurawsky, Suzanne Scarlata

Regulation of the activity of the promoter of RNA-induced silencing, C3PO
Protein Sci. 2017  July 16


Yang L, Scarlata S.

Super-resolution Visualization of Caveola Deformation in Response to Osmotic Stress.
J Biol Chem. 2017 Mar 3



Philip F, Sahu S, Golebiewska U, Scarlata S.
RNA-induced silencing attenuates G protein-mediated calcium signals. 2016 May;30(5):1958-67.


RNA-induced silencing attenuates G protein-mediated calcium signals.
Philip F, Sahu S, Golebiewska U, Scarlata S
FASEB J. 2016 May


Scarlata S, Garwain O, Williams L, Burguera IG, Rosati B, Sahu S, Guo Y, Philip F, Golebiewska U.

Phospholipase Cβ connects G protein signaling with RNA interference.
Adv Biol Regul. 2016 May


Scarlata S.

Watching Signaling in Action: Single Molecule Studies of a Reaction Circuit Involved in Chemotaxis.
Biophys J. 2016 Apr 26


Sette P, O’Connor SK, Yerramilli VS, Dussupt V, Nagashima K, Chutiraka K, Lingappa J, Scarlata S, Bouamr F.

HIV-1 Nucleocapsid Mimics the Membrane Adaptor Syntenin PDZ to Gain Access to ESCRTs and Promote Virus Budding.
Cell Host Microbe. 2016 Mar 9


Sette P, O’Connor SK, Yerramilli VS, Dussupt V, Nagashima K, Chutiraka K, Lingappa J, Scarlata S, Bouamr F.
HIV-1 Nucleocapsid Mimics the Membrane Adaptor Syntenin PDZ to Gain Access to ESCRTs and Promote Virus Budding. Cell Host Microbe. 2016 Mar;19(3):336-48.


Yerramilli VS, Scarlata S.

The breast cancer susceptibility gene product (γ-synuclein) alters cell behavior through it interaction with phospholipase Cβ.
Cell Signal. 2016 Jan;28(1):91-9.


Garwain O, Scarlata S.

Phospholipase Cβ-TRAX Association Is Required for PC12 Cell Differentiation.
J Biol Chem. 2016 Oct



Golebiewska U, Scarlata S.

High pressure promotes alpha-synuclein aggregation in cultured neuronal cells.
FEBS Lett. 2015 Oct 24;589(21):3309-12.


Guo Y, Yang L, Haught K, Scarlata S.

Osmotic Stress Reduces Ca2+ Signals through Deformation of Caveolae.
J Biol Chem. 2015 Jul 3;290(27):16698-707


Guo Y, Lu Z, Cohen IS, Scarlata S.

Development of a universal RNA beacon for exogenous gene detection.
Stem Cells Transl Med. 2015 May;4(5):476-82.


Loew L, Beckett D, Egelman EH, Scarlata S.

Reproducibility of research in biophysics.
Biophys J. 2015 Apr 7;108(7):E1. doi: 10.1016/j.bpj.2015.03.002



Scarlata S, Golebiewska U .
Alpha-synuclein properties with oxidation: a hypothesis on a mechanism underling cellular aggregation.
J Bioenerg Biomembr. 2014 Apr;46(2):93-8


Golebiewska U, Zurawsky C, Scarlata S
Defining the oligomerization state of γ-synuclein in solution
Biochemistry (2014) 53(2):293-9


Sahu, S., Philip, F. Scarlata, S
Hydrolysis Rates of Different Small Interfering RNAs (siRNAs) by the RNA Silencing Promoter Complex, C3PO, Determines Their Regulation by Phospholipase Cβ
Journal of Biological Chemistry (2014) 289, 5134-5144



Philip F, Sahu S, Caso G, Scarlata S.
Role of phospholipase C-β in RNA interference.
Adv Biol Regul. 2013 Jul 18.


Rangamani, P., Lipshtat, A., Azeloglu, E., Calizo, RC., Scarlata, S., Neves, S., Iyengar, R.
Decoding information in cell shape.
Cell 2013 Sep 12;154(6):1356-69


Calizo, RC, Scarlata, S.
Discrepancy between FCS and FRAP diffusion measurements of G protein coupled receptors.
Anal Biochem . 201: S0003-2697(13)00254-6..


Guo Y, Scarlata S. 
A loss in cellular protein partners promotes α-synuclein aggregation in cells resulting from oxidative stress.  Biochemistry (2013) 52, 3913-20.



Calizo, RC., Scarlata, S.
A role for G-proteins in directing G-protein-coupled receptor-caveolae localization.
Biochemistry (2012) 51, 9513-23


Philip, F., Guo, Y., Aisiku, O., Scarlata, S.
Phospholipase Cβ1 is linked to RNA interference of specific genes through translin-associated factor X.
FASEB J. (2012) 26, 4903-13.


Golebiewska, U.,  Guo, Y.,  Khalikaprasad, N., Zurawsky, C., Yerramilli, V.S., Scarlata, S
γ-Synuclein interacts with Phospholipase Cβ2 to Modulate G Protein Activation.
PLoS ONE (2012) 7, e41067. doi:10.1371/journal.pone.0041067


Guo Y., Rosati B., Scarlata S.
α-Synuclein increases the cellular level of phospholipase Cβ1.
Cellular Signaling (2012) 24, 1109-1114.



Golebiewska, U. and Scarlata, S.
Measuring fast calcium fluxes in fardiomyocytes.(2011)
Journal  of Visualized Experiments


Golebiewska U., Kay J.G., Masters T., Grinstein S., Im W., Pastor R.W., Scarlata S., McLaughlin S.
Evidence for a fence that impedes the diffusion of phosphatidylinositol 4,5-bisphosphate out of the forming phagosomes of macrophages.
Mol Biol Cell. (2011) 22, 3498-3507.


Han D.S., Golebiewska U., Stolzenberg S., Scarlata S., Weinstein H.
A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits.
Mol Pharmacol . (2011) 80, 434-45.


Weinstein H., Scarlata S.
The correlation between multidomain enzymes and multiple activation mechanisms- The case of phospholipase Cβ and its membrane interactions.
Biochim Biophys Acta . (2011)


Guo Y, Golebiewska U, Scarlata S
Modulation of Ca 2+ activity in Cardiomyocytes through Caveolae – Gaq Interactions
Biophysical Journal 2011


Golebiewska U, Johnston JM, Devi LA, Filizola M, Scarlata SF.
Differential Response to Morphine of the Oligomeric State of μ- Opioid in the Presence of δ- Opioid Receptors.
Biochemistry. 2011


Aisiku O, Dowal L, Scarlata S.
Protein kinase C phosphorylation of PLCβ1 regulates its cellular localization.
Arch Biochem Biophys. 2011


2010 and beyond

Aisiku OR, Runnels LW, Scarlata S.
Identification of a novel binding partner of phospholipase cβ1: translin-associated factor X.
PLoS One. 2010 Nov 29;5(11)

Guo Y, Golebiewska U, D’Amico S, Scarlata S.
The small G protein Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2.
J Biol Chem. 2010 Aug 6;285(32):24999-5008.

Golebiewska U, Scarlata S.
The effect of membrane domains on the G protein-phospholipase Cbeta signaling pathway.
Crit Rev Biochem Mol Biol. 2010 Apr;45(2):97-105

Li W, Scarlata S, Miller WT.
Evidence for convergent evolution in the signaling properties of a choanoflagellate tyrosine kinase.
Biochemistry. 2009 Jun 16;48(23):5180-6.

Wang J, Sengupta P, Guo Y, Golebiewska U, Scarlata S.
Evidence for a second, high affinity Gbetagamma binding site on Galphai1(GDP) subunits.
J Biol Chem. 2009 Jun 19;284(25):16906-13.

Wang J, Golebiewska U, Scarlata S.
A self-scaffolding model for G protein signaling.
J Mol Biol. 2009 Mar 20;387(1):92-103.

Rebecchi MJ, Raghubir A, Scarlata S, Hartenstine MJ, Brown T, Stallings JD.
Expression and function of phospholipase C in breast carcinoma.
Adv Enzyme Regul. 2009;49(1):59-73.

Royer CA, Scarlata SF.
Fluorescence approaches to quantifying biomolecular interactions.
Methods Enzymol. 2008;450:79-106. Review.

Golebiewska U, Scarlata S.
Galphaq binds two effectors separately in cells: evidence for predetermined signaling pathways.
Biophys J. 2008 Sep;95(5):2575-8

Sengupta P, Philip F, Scarlata S.
Caveolin-1 alters Ca(2+) signal duration through specific interaction with the G alpha q family of G proteins.
J Cell Sci. 2008 May 1;121(Pt 9):1363-72. Epub

Audie J, Scarlata S.
A novel empirical free energy function that explains and predicts protein-protein binding affinities.
Biophys Chem. 2007 Sep;129(2-3):198-211. Epub 2007 Jun 7.

Drin G, Scarlata S.
Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding–how many ways can you activate an enzyme?
Cell Signal. 2007 Jul;19(7):1383-92. Epub 2007 Apr 29. Review.

Philip F, Sengupta P, Scarlata S.
Signaling through a G Protein-coupled receptor and its corresponding G protein follows a stoichiometrically limited model.
J Biol Chem. 2007 Jun 29;282(26):19203-16. Epub 2007 Apr 9.

Philip F, Scarlata S.
Real-time measurements of protein affinities on membrane surfaces by fluorescence spectroscopy.
Sci STKE. 2006 Aug 29;2006(350):pl5.

Dowal L, Provitera P, Scarlata S.
Stable association between G alpha(q) and phospholipase C beta 1 in living cells.
J Biol Chem. 2006 Aug 18;281(33):23999-4014. Epub 2006 Jun 5.

Drin G, Douguet D, Scarlata S.
The pleckstrin homology domain of phospholipase Cbeta transmits enzymatic activation through modulation of the membrane-domain orientation.
Biochemistry. 2006 May 9;45(18):5712-24.

Ballou LM, Chattopadhyay M, Li Y, Scarlata S, Lin RZ.
Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras.
Biochem J. 2006 Mar 15;394(Pt 3):557-62.

Provitera P, El-Maghrabi R, Scarlata S.
The effect of HIV-1 Gag myristoylation on membrane binding.
Biophys Chem. 2006 Jan 1;119(1):23-32. Epub 2005 Sep 23.

Scarlata S.
The effect of hydrostatic pressure on membrane-bound proteins.
Braz J Med Biol Res. 2005 Aug;38(8):1203-8. Epub 2005 Jul 30. Review.

Kulisz A, Dowal L, Scarlata S, Shen SS.
Cloning and characterization of a phospholipase C-beta isoform from the sea urchin Lytechinus pictus.
Dev Growth Differ. 2005 Jun;47(5):307-21.

Feng J, Roberts MF, Drin G, Scarlata S.
Dissection of the steps of phospholipase C beta 2 activity that are enhanced by G beta gamma subunits.
Biochemistry. 2005 Feb 22;44(7):2577-84.

Scarlata S.
Determination of the activation volume of PLCbeta by Gbeta gamma-subunits through the use of high hydrostatic pressure.
Biophys J. 2005 Apr;88(4):2867-74. Epub 2005 Jan 21.

Narayanan V, Guo Y, Scarlata S.
Fluorescence studies suggest a role for alpha-synuclein in the phosphatidylinositol lipid signaling pathway.
Biochemistry. 2005 Jan 18;44(2):462-70.

Bon Homme M, Carter C, Scarlata S.
The cysteine residues of HIV-1 capsid regulate oligomerization and cyclophilin A-induced changes.
Biophys J. 2005 Mar;88(3):2078-88. Epub 2004 Dec 30.

Guo Y, Rebecchi M, Scarlata S.
Phospholipase Cbeta2 binds to and inhibits phospholipase Cdelta1.
J Biol Chem. 2005 Jan 14;280(2):1438-47. Epub 2004 Oct 27.

Philip F, Scarlata S.
Influence of membrane components in the binding of proteins to membrane surfaces.
Biochemistry. 2004 Sep 21;43(37):11691-700.

Jeromin A, Muralidhar D, Parameswaran MN, Roder J, Fairwell T, Scarlata S, Dowal L, Mustafi SM, Chary KV, Sharma Y.
N-terminal myristoylation regulates calcium-induced conformational changes in neuronal calcium sensor-1.
J Biol Chem. 2004 Jun 25;279(26):27158-67. Epub 2004 Apr 21.

Scarlata S, Dowal L.
The use of green fluorescent proteins to view association between phospholipase C beta and G protein subunits in cells. Methods Mol Biol. 2004;237:223-32. Review.

BonHomme M, Wong S, Carter C, Scarlata S.
The pH dependence of HIV-1 capsid assembly and its interaction with cyclophilin A.
Biophys Chem. 2003 Aug 1;105(1):67-77.

Scarlata S, Carter C.
Role of HIV-1 Gag domains in viral assembly.
Biochim Biophys Acta. 2003 Jul 11;1614(1):62-72. Review.

Bouamr F, Scarlata S, Carter C.
Role of myristylation in HIV-1 Gag assembly.
Biochemistry. 2003 Jun 3;42(21):6408-17.

Guo Y, Philip F, Scarlata S.
The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site.
J Biol Chem. 2003 Aug 8;278(32):29995-30004. Epub 2003 May 21.

Philip F, Guo Y, Scarlata S.
Multiple roles of pleckstrin homology domains in phospholipase Cbeta function.
FEBS Lett. 2002 Oct 30;531(1):28-32. Review.

Buck E, Schatz P, Scarlata S, Iyengar R.
Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2.
J Biol Chem. 2002 Dec 20;277(51):49707-15. Epub 2002 Oct 17.

Scarlata S.
Regulation of the lateral association of phospholipase Cbeta2 and G protein subunits by lipid rafts.
Biochemistry. 2002 Jun 4;41(22):7092-9.

Scarlata S.
Determination of strength and specificity of membrane-bound G protein–phospholipase C association using fluorescence spectroscopy.
Methods Enzymol. 2002;345:306-27. No abstract available.

Fogg VC, Azpiazu I, Linder ME, Smrcka A, Scarlata S, Gautam N.
Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta.
J Biol Chem. 2001 Nov 9;276(45):41797-802. Epub 2001 Sep 6.

Narayanan V, Scarlata S.
Membrane binding and self-association of alpha-synucleins.
Biochemistry. 2001 Aug 21;40(33):9927-34.

Ehrlich LS, Liu T, Scarlata S, Chu B, Carter CA.
HIV-1 capsid protein forms spherical (immature-like) and tubular (mature-like) particles in vitro: structure switching by pH-induced conformational changes.
Biophys J. 2001 Jul;81(1):586-94. Erratum in: Biophys J 2001 Nov;81(5):2992.

Provitera P, Goff A, Harenberg A, Bouamr F, Carter C, Scarlata S.
Role of the major homology region in assembly of HIV-1 Gag.
Biochemistry. 2001 May 8;40(18):5565-72.

Dowal L, Elliott J, Popov S, Wilkie TM, Scarlata S.
Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1.
Biochemistry. 2001 Jan 16;40(2):414-21.

Provitera P, Bouamr F, Murray D, Carter C, Scarlata S.
Binding of equine infectious anemia virus matrix protein to membrane bilayers involves multiple interactions.
J Mol Biol. 2000 Feb 25;296(3):887-98.

Wang T, Dowal L, El-Maghrabi MR, Rebecchi M, Scarlata S.
The pleckstrin homology domain of phospholipase C-beta(2) links the binding of gbetagamma to activation of the catalytic core.
J Biol Chem. 2000 Mar 17;275(11):7466-9.

Martin DW, Marecek J, Scarlata S, Sachs JR.
Alphabeta protomers of Na+,K+-ATPase from microsomes of duck salt gland are mostly monomeric: formation of higher oligomers does not modify molecular activity.
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3195-200.

Rebecchi M, Bonhomme M, Scarlata S.
Role of lipid packing in the activity of phospholipase C-delta1 as determined by hydrostatic pressure measurements.
Biochem J. 1999 Aug 1;341 ( Pt 3):571-6.

Wang T, Pentyala S, Elliott JT, Dowal L, Gupta E, Rebecchi MJ, Scarlata S.
Selective interaction of the C2 domains of phospholipase C-beta1 and -beta2 with activated Galphaq subunits: an alternative function for C2-signaling modules.
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7843-6.

Denisova E, Dowling W, LaMonica R, Shaw R, Scarlata S, Ruggeri F, Mackow ER.
Rotavirus capsid protein VP5* permeabilizes membranes. J Virol. 1999 Apr;73(4):3147-53.

Buck E, Li J, Chen Y, Weng G, Scarlata S, Iyengar R.
Resolution of a signal transfer region from a general binding domain in gbeta for stimulation of phospholipase C-beta2.
Science. 1999 Feb 26;283(5406):1332-5.
Wang T, Pentyala S, Rebecchi MJ, Scarlata S.
Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins.
Biochemistry. 1999 Feb 2;38(5):1517-24.

Runnels LW, Scarlata SF.
Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-beta effectors.
Biochemistry. 1999 Feb 2;38(5):1488-96.

Runnels LW, Scarlata SF.
Regulation of the rate and extent of phospholipase C beta 2 effector activation by the beta gamma subunits of heterotrimeric G proteins.
Biochemistry. 1998 Nov 3;37(44):15563-74.

Rebecchi MJ, Scarlata S.
Pleckstrin homology domains: a common fold with diverse functions.
Annu Rev Biophys Biomol Struct. 1998;27:503-28. Review.

Scarlata S, Ehrlich LS, Carter CA.
Membrane-induced alterations in HIV-1 Gag and matrix protein-protein interactions.
J Mol Biol. 1998 Mar 27;277(2):161-9.

Scarlata SF.
Effects of cholesterol on membrane surfaces as studied by high-pressure fluorescence spectroscopy.
Biophys Chem. 1997 Nov;69(1):9-21.

Scarlata S, Gruner SM.
Role of phosphatidylethanolamine lipids in the stabilization of protein-lipid contacts.
Biophys Chem. 1997 Sep 1;67(1-3):269-79.

Morris AJ, Scarlata S.
Regulation of effectors by G-protein alpha- and beta gamma-subunits. Recent insights from studies of the phospholipase c-beta isoenzymes.
Biochem Pharmacol. 1997 Aug 15;54(4):429-35. Review.

Lee J, Pilch PF, Shoelson SE, Scarlata SF.
Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy.
Biochemistry. 1997 Mar 4;36(9):2701-8.

Runnels LW, Jenco J, Morris A, Scarlata S.
Membrane binding of phospholipases C-beta 1 and C-beta 2 is independent of phosphatidylinositol 4,5-bisphosphate and the alpha and beta gamma subunits of G proteins.
Biochemistry. 1996 Dec 24;35(51):16824-32.

Scarlata S, Gupta R, Garcia P, Keach H, Shah S, Kasireddy CR, Bittman R, Rebecchi MJ.
Inhibition of phospholipase C-delta 1 catalytic activity by sphingomyelin.
Biochemistry. 1996 Nov 26;35(47):14882-8.

Ebbets-Reed D, Scarlata S, Carter CA.
The major homology region of the HIV-1 gag precursor influences membrane affinity.
Biochemistry. 1996 Nov 12;35(45):14268-75.

Glaser M, Wanaski S, Buser CA, Boguslavsky V, Rashidzada W, Morris A, Rebecchi M, Scarlata SF, Runnels LW, Prestwich GD, Chen J, Aderem A, Ahn J, McLaughlin S.
Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains.
J Biol Chem. 1996 Oct 18;271(42):26187-93.

Ehrlich LS, Fong S, Scarlata S, Zybarth G, Carter C.
Partitioning of HIV-1 Gag and Gag-related proteins to membranes.
Biochemistry. 1996 Apr 2;35(13):3933-43.

Garcia P, Gupta R, Shah S, Morris AJ, Rudge SA, Scarlata S, Petrova V, McLaughlin S, Rebecchi MJ.
The pleckstrin homology domain of phospholipase C-delta 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes.
Biochemistry. 1995 Dec 12;34(49):16228-34.

Scarlata S, Miksicek R.
Binding properties of coumestrol to expressed human estrogen receptor.
Mol Cell Endocrinol. 1995 Nov 30;115(1):65-72.

Runnels LW, Scarlata SF.
Theory and application of fluorescence homotransfer to melittin oligomerization.
Biophys J. 1995 Oct;69(4):1569-83.

Scarlata S, McBath H, Haspel HC.
Effect of lipid packing on the conformational states of purified GLUT-1 hexose transporter.
Biochemistry. 1995 Jun 13;34(23):7703-11.

Honkanen RA, McBath H, Kushmerick C, Callender GE, Scarlata SF, Fenstermacher JD, Haspel HC.
Barbiturates inhibit hexose transport in cultured mammalian cells and human erythrocytes and interact directly with purified GLUT-1.
Biochemistry. 1995 Jan 17;34(2):535-44.

Hirsch RE, Friedman JM, Harrington JR, Scarlata SF, Harrington JP.
Stability of a potential blood substitute, HbXL99 alpha, under high pressure.
Biochem Biophys Res Commun. 1994 May 16;200(3):1635-40. Erratum in: Biochem Biophys Res Commun 1994 Jul 15;202(1):645.

Teng Q, Scarlata S.
Effect of high pressure on the association of melittin to membranes.
J Biol Chem. 1993 Jun 15;268(17):12434-42.

Montich G, Scarlata S, McLaughlin S, Lehrmann R, Seelig J.
Thermodynamic characterization of the association of small basic peptides with membranes containing acidic lipids.
Biochim Biophys Acta. 1993 Feb 23;1146(1):17-24.

Hirsch RE, Harrington JP, Scarlata SF.
The differential effects of carbon monoxide and oxygen on the pressure dissociation of Lumbricus terrestris hemoglobin.
Biochim Biophys Acta. 1993 Feb 13;1161(2-3):285-90.

Sassaroli M, Vauhkonen M, Somerharju P, Scarlata S.
Dipyrenylphosphatidylcholines as membrane fluidity probes. Pressure and temperature dependence of the intramolecular excimer formation rate.
Biophys J. 1993 Jan;64(1):137-49.

Zakim D, Kavecansky J, Scarlata S.
Are membrane enzymes regulated by the viscosity of the membrane environment?
Biochemistry. 1992 Nov 24;31(46):11589-94.

Noy N, Slosberg E, Scarlata S.
Interactions of retinol with binding proteins: studies with retinol-binding protein and with transthyretin.
Biochemistry. 1992 Nov 17;31(45):11118-24.

Dannenberg AJ, Worman HJ, Scarlata S.
Developmental changes in the amount and functional state of UDP-glucuronosyltransferase.
Biochim Biophys Acta. 1992 Jun 12;1116(3):250-5.

Royer CA, Ropp T, Scarlata SF.
Solution studies of the interactions between the histone core proteins and DNA using fluorescence spectroscopy.
Biophys Chem. 1992 Jun;43(2):197-211. Erratum in: Biophys Chem 1993 May;46(3):295-6.

Scarlata SF.
Effect of increased chain packing on gramicidin-lipid interactions.
Biochemistry. 1991 Oct 15;30(41):9853-9.

Breslow E, LaBorde T, Bamezai S, Scarlata S.
Binding and fluorescence studies of the relationship between neurophysin-peptide interaction and neurophysin self-association: an allosteric system exhibiting minimal cooperativity.
Biochemistry. 1991 Aug 13;30(32):7990-8000.

Teng Q, Koeppe RE 2nd, Scarlata SF.
Effect of salt and membrane fluidity on fluorophore motions of a gramicidin C derivative.
Biochemistry. 1991 Aug 13;30(32):7984-90.

Scarlata SF.
Compression of lipid membranes as observed at varying membrane positions.
Biophys J. 1991 Aug;60(2):334-40.

Scarlata SF, Rosenberg M.
Effect of increased lipid packing on the surface charge of micelles and membranes.
Biochemistry. 1990 Nov 6;29(44):10233-40.

Dannenberg AJ, Kavecansky J, Scarlata S, Zakim D.
Organization of microsomal UDP-glucuronosyltransferase. Activation by treatment at high pressure.
Biochemistry. 1990 Jun 26;29(25):5961-7.

Scarlata SF, Ropp T, Royer CA.
Histone subunit interactions as investigated by high pressure.
Biochemistry. 1989 Aug 8;28(16):6637-41.

Royer CA, Rusch RM, Scarlata SF.
Salt effects on histone subunit interactions as studied by fluorescence spectroscopy.
Biochemistry. 1989 Aug 8;28(16):6631-7.

Scarlata SF.
Evaluation of the thermal coefficient of the resistance to fluorophore rotation in model membranes.
Biophys J. 1989 Jun;55(6):1215-23.

Scarlata SF.
The effects of viscosity on gramicidin tryptophan rotational motion.
Biophys J. 1988 Dec;54(6):1149-57.

Eisinger J, Scarlata SF.
The lateral fluidity of erythrocyte membranes. Temperature and pressure dependence.
Biophys Chem. 1987 Dec;28(3):273-81.

Scarlata SF, Royer CA.
Ligand-induced asymmetry as observed through fluorophore rotations and free energy couplings: application to neurophysin. Biochemistry. 1986 Aug 26;25(17):4925-9.

Fisher MT, Scarlata SF, Sligar SG.
High-pressure investigations of cytochrome P-450 spin and substrate binding equilibria.
Arch Biochem Biophys. 1985 Jul;240(1):456-63.